Alan Bellows wrote(all italicized):
Chemically,scopolamine, sodium amytal, and Sodium Pentothal are the base element of so-called 'Truth Serum'.Scopolamine was tested in the 1950s as a truth serum in project MKULTRA, and is now infamous as a date-rape drug due to its tendency to cause retrograde amnesia (the inability to recall events prior to its administration). Sodium Pentothal is a drug which is commonly used in operating rooms as general anesthesia, though in recent years it has been largely replaced by better alternatives.

Another of the most common truth serums is ethyl alcohol, the same agent that is found in alcoholic beverages. As a truth serum, it is usually injected in a nearly pure form, but its effects are indistinguishable from those caused by consuming large amounts of alcohol orally. If you've ever been intoxicated, then you are personally familiar with the effects that truth serum has on the mind and body.

Wikipedia writes " A truth drug (or truth serum) is a drug used for the purposes of obtaining accurate information from an unwilling subject, most often by a police, intelligence, or military organization on a prisoner. Effective truth drugs are mostly fictional, though some drugs have been shown to be effective in lowering the resistance (but sometimes also reliability) of an interrogated person. "
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